Nuclear receptor co-repressor 2

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Protein NCOR2 PDB 1xc5.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesNCOR2, CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1, nuclear receptor corepressor 2
External IDsOMIM: 600848 MGI: 1337080 HomoloGene: 31370 GeneCards: NCOR2
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for NCOR2
Genomic location for NCOR2
Band12q24.31Start124,324,415 bp[1]
End124,567,589 bp[1]
RNA expression pattern
PBB GE NCOR2 208888 s at fs.png

PBB GE NCOR2 207760 s at fs.png

PBB GE NCOR2 208889 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 12: 124.32 – 124.57 MbChr 5: 125.02 – 125.18 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target gene expression.[5][6] NCOR2 is also referred to as a silencing mediator for retinoid or thyroid-hormone receptors (SMRT)[5] or T3 receptor-associating cofactor 1 (TRAC-1).[6]


NCOR2/SMRT is a transcriptional coregulatory protein that contains several modulatory functional domains including multiple autonomous repression domains as well as two or three C-terminal nuclear receptor-interacting domains.[5] NCOR2/SMRT serves as a repressive coregulatory factor (corepressor) for multiple transcription factor pathways. In this regard, NCOR2/SMRT functions as a platform protein, facilitating the recruitment of histone deacetylases to the DNA promoters bound by its interacting transcription factors.[7]


It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 1.[8]


SMRT was initially cloned and characterized in the laboratory of Dr. Ronald M. Evans at the Salk Institute for Biological Studies.[5] In another early investigation into this molecule, similar findings were reported in a variant referred to as TRAC-1.[6]


Nuclear receptor co-repressor 2 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196498 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029478 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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  6. ^ a b c Sande S, Privalsky ML (July 1996). "Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors". Molecular Endocrinology. 10 (7): 813–25. doi:10.1210/me.10.7.813. PMID 8813722.
  7. ^ Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM (May 1997). "Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase". Cell. 89 (3): 373–80. doi:10.1016/S0092-8674(00)80218-4. PMID 9150137. S2CID 14686941.
  8. ^ UniProt Nuclear receptor corepressors family Page accessed June 26, 2016
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