CRTC1

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CRTC1
Identifiers
AliasesCRTC1, MECT1, TORC-1, TORC1, WAMTP1, CREB regulated transcription coactivator 1, MAML2, Mam-2
External IDsOMIM: 607536 MGI: 2142523 HomoloGene: 41607 GeneCards: CRTC1
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for CRTC1
Genomic location for CRTC1
Band19p13.11Start18,683,678 bp[1]
End18,782,333 bp[1]
RNA expression pattern
PBB GE CRTC1 207159 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001098482
NM_015321
NM_025021

NM_001004062

RefSeq (protein)

NP_001091952
NP_056136

NP_001004062

Location (UCSC)Chr 19: 18.68 – 18.78 MbChr 8: 70.38 – 70.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1), is a protein that in humans is encoded by the CRTC1 gene.[5][6][7][8] It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands[9] and various regions of the adult central nervous system.[10]

Clinical significance[edit]

Production of CRTC1 is blocked in Alzheimer's disease.[11] TORC1 might be the target protein in ketamin induced anti-depressent effect via NMDA-antagonisation.

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105662 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003575 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (Feb 2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nature Genetics. 33 (2): 208–13. doi:10.1038/ng1083. PMID 12539049. S2CID 23417795.
  6. ^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
  7. ^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
  8. ^ "Entrez Gene: CRTC1 CREB regulated transcription coactivator 1".
  9. ^ Huret J-L. "CRTC1 (CREB regulated transcription coactivator 1)". Atlas of Genetics and Cytogenetics in Oncology and Haematology. INSERM U 935, Genetics, Dept Medical Information, University Hospital of Poitiers.
  10. ^ Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR (Mar 2007). "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity". Proceedings of the National Academy of Sciences of the United States of America. 104 (11): 4700–5. doi:10.1073/pnas.0607524104. PMC 1838663. PMID 17360587.
  11. ^ Parra-Damas A, Valero J, Chen M, España J, Martín E, Ferrer I, Rodríguez-Alvarez J, Saura CA (Apr 2014). "Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages". The Journal of Neuroscience. 34 (17): 5776–87. doi:10.1523/JNEUROSCI.5288-13.2014. PMC 6608295. PMID 24760838.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.